Columbus Blue Jackets vs Buffalo Sabres Prediction, Picks & Odds — Nov 6

Fri, Nov 6, 7:00 PM ET · KeyBank Center · NHL

Open the game card for live odds, every market and the full prediction.

Columbus Blue Jackets at Buffalo Sabres is on Friday, November 6, 2026, at KeyBank Center. Averaged over the outcomes the betting lines imply, the projected score is Columbus Blue Jackets 3, Buffalo Sabres 4. That is an average, not a pick.

The story

The Columbus Blue Jackets have won 6 of their 13 games this season, winning three of the last five. The Buffalo Sabres have won 7 of their 15 games this season, winning three of the last five. When these teams last met, on October 1, 2026, the Columbus Blue Jackets won 6-3 at home. This is their second meeting this season.

Matchups to watch

Moneyline

The betting market, with the margin removed, gives Buffalo Sabres a 61.7% chance to beat Columbus Blue Jackets. AiQ's moneyline pick is the side the consensus favors. The best price, -170 at Fanatics, is priced below the fair price of -161 (−2.1% value).

Total

The betting market, with the margin removed, puts the over 6.5 goals at 47.9% and the under at 52.1%. That is near a coin flip, and AiQ's read is the market's own, so AiQ has no edge on the total. AiQ's projected total, 6.4 goals, sits on the 6.5 line.

Puck line

The betting market, with the margin removed, gives Columbus Blue Jackets +1.5 a 61.8% chance to cover and Buffalo Sabres -1.5 38.2%. AiQ's read matches the market price, so AiQ has no edge on the puck line.

Recent results against the puck line back the Columbus Blue Jackets, the underdog here. The Buffalo Sabres failed to cover the puck line in 5 of 5 home games this season.

Recent totals lean under. The Buffalo Sabres went under the total in 4 of 5 home games this season.

These come from the closing lines of this season and last. They are context, not the reason for AiQ's picks, and the books price them in.

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