Detroit Lions defeat Arizona Cardinals 45-21: Recap, Betting Results & AiQ Picks
Sun, Oct 11, 2026 · NFL · Detroit Lions 45, Arizona Cardinals 21
Detroit Lions dominated Arizona Cardinals 45-21 on Sunday, covering the -5.5 spread and going over the total to 66 points, 11 over the 55 line.
Detroit Lions vs. Arizona Cardinals final score and game recap
Detroit built a 24-7 halftime lead, then extended it to 38-14 by the end of the third quarter. Arizona won the opening quarter 7-0, but Detroit responded with 24 unanswered points in the second period. The Cardinals managed only 14 points across the final two quarters while the Lions added 21 more.
Jared Goff led the Lions' offense with 19-of-30 passing for 271 yards and three touchdowns. Jahmyr Gibbs carried 25 times for 151 yards and two rushing scores. For Arizona, Jacoby Brissett threw for 292 yards and three touchdowns but also one interception. Tight end Trey McBride caught nine passes for 66 yards and a touchdown.
Who covered the spread in Detroit Lions vs. Arizona Cardinals?
Detroit covered as a -5.5 favorite, winning by 24 points. The spread held steady from open to close.
Did Detroit Lions vs. Arizona Cardinals go over or under the total?
The game went over 55, finishing at 66 points—an 11-point overage. The total opened at 54.5 and moved up 0.5 to 55 at close.
How did AiQ's Detroit Lions vs. Arizona Cardinals predictions do?
AiQ finished 28-33 across all graded picks on this game.
- Moneyline: Detroit Lions at -253 — WIN (+$39.53 on a $100 bet)
- Player props: 27-33
The model correctly identified the Lions as winners and the over but missed several player prop lines, particularly on passing yards.
Detroit Lions vs. Arizona Cardinals player prop results
AiQ's player prop record was 27-33.
- Michael Wilson under 80.5 receiving yards — WIN (30 yards)
- Jacoby Brissett under 271.5 passing yards — LOSS (292 yards)
- Tyler Allgeier under 27.5 rushing yards — WIN (7 yards)
- Jeremiyah Love over 11.5 rushing attempts — WIN (12 attempts)
- Jeremiyah Love over 45.5 rushing yards — LOSS (22 yards)
- Jacoby Brissett under 282.5 passing yards — LOSS (311 yards)
- Trey McBride under 85.5 receiving yards — WIN (66 yards)
- Jeremiyah Love over 61.5 rush reception yards — LOSS (22 yards)
- Jared Goff over 288.5 passing yards — LOSS (272 yards)
- Michael Wilson over 6.5 receptions — LOSS (4 receptions)
- Isaac TeSlaa over 25.5 receiving yards — LOSS (0 yards)
- Jeremiyah Love over 2.5 receptions — LOSS (0 receptions)
Detroit Lions vs. Arizona Cardinals game prop results: first quarter, team totals and first half
- First-quarter moneyline: Arizona Cardinals won the first quarter (+130)
- Detroit Lions team total 30.5: Over (-113); Lions scored 45
- Arizona Cardinals team total 24.5: Under (-113); Cardinals scored 21
- First-half spread: Detroit Lions -3.5 covered (-102)
- First-half moneyline: Detroit Lions won the first half (-192)
- First-half total 26.5: Over (-125); 31 points scored
- First-quarter total 10.5: Under (-135); 7 points scored
Detroit Lions vs. Arizona Cardinals odds: sportsbook value and line movement
The closing moneyline was Detroit Lions -253 against Arizona Cardinals +205. The bookmaker's margin was 4.5%. A $100 wager on the Lions at -253 returned $39.53 profit. AiQ's moneyline estimate was calibrated at 69%, matching the market, but the best available price was -240 at BetRivers—a -1.7% expected value. The model liked the side but not the price. The spread held steady from open to close, while the total moved up 0.5 points from 54.5 to 55.
Detroit Lions and Arizona Cardinals betting trends: 2026 season
Detroit sits 3-2 overall: 2-0 at home, 1-2 away. Against the spread in five games with a closing line, the Lions are 1-3-1. They have hit the over in all five games with a recorded total. Their last five results: W, L, W, L, W.
Arizona is 1-4 overall: 0-2 at home, 1-2 away. The Cardinals are 2-3 against the spread in five games and 3-2 on the over-under. Their last five results: L, L, L, L, W, extending a four-game losing streak.
What's next for Detroit Lions and Arizona Cardinals?
The Lions host the Green Bay Packers on Sunday, October 25. The Cardinals host the Denver Broncos on the same day.